Qsymia® is for adults with a BMI* of 30 or more and should be used with a reduced-calorie diet and increased physical activity for chronic weight management.

Qsymia dosing

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People who stayed on Qsymia lost an average of 25 pounds

Depending on dose.

In one clinical study, overweight (BMI* of 27 or greater) and obese patients received either Qsymia 7.5 mg/46 mg, Qsymia 15 mg/92 mg, or placebo for one year.

  • Patients had two or more obesity-related conditions such as elevated blood pressure or taking two or more antihypertensive medications, high cholesterol or taking two or more medications to treat high cholesterol, elevated blood sugar or diabetes, or a waist measurement 40 inches or greater for men or 35 inches or greater for women
  • It was recommended that patients reduce their caloric intake by 500 kcal/day
  • The average BMI of the patients at the start of the study was 37
     

Possible side effects of Qsymia include mood changes and trouble sleeping; concentration, memory, and speech difficulties; increases of acid in bloodstream (metabolic acidosis); low blood sugar (hypoglycemia) in people with type 2 diabetes mellitus who also take medicines used to treat type 2 diabetes mellitus; the possible need to adjust medicines for high blood pressure; increases in central nervous system (CNS) symptoms when used with prescription sleep aids, anxiety medicine, or when drinking alcohol; possible seizures if you stop taking Qsymia too fast; kidney stones; and decreased sweating and increased body temperature (fever).

Tell your healthcare provider if you have any side effect that bothers you or does not go away.

FDA-approved prescription Qsymia for weight loss

Learn about achieving long-term weight‑loss results with prescription Qsymia.

Qsymia is a 2-in-1 prescription weight-loss medicine which can help you lose weight and keep it off

Take Qsymia with a reduced calorie diet and increased activity

Qsymia is a once-daily pill that should be used with a reduced calorie diet and increased physical activity.

  • Take Qsymia exactly as your healthcare provider tells you to take it

  • Your healthcare provider should start you on a diet and exercise program when you start taking Qsymia. Stay on this program while you are taking Qsymia

  • Your healthcare provider will tell you how much Qsymia to take and when to take it
    • Do not change your dose without talking to your healthcare provider
    • Take Qsymia 1 time a day in the morning
    • Qsymia can be taken with or without food
    • If you miss a dose of Qsymia, wait until the next morning to take your usual dose of Qsymia. Do not double your dose
  • Your healthcare provider should either (1) tell you to stop taking Qsymia or (2) increase your dose of Qsymia if you do not lose a certain amount of weight within the first 12 weeks of treatment at the recommended dose. If your healthcare provider increases your dose of Qsymia, he/she should tell you to stop taking Qsymia if you have not lost a certain amount of weight after an additional 12 weeks of treatment on the higher dose

  • Do not stop taking Qsymia without talking to your healthcare provider. Stopping Qsymia suddenly can cause serious problems, such as seizures. Your healthcare provider will tell you how to stop taking Qsymia slowly

  • Before you take Qsymia, check to make sure that you are taking the right dose:

    Starting

    3.75 mg/​23 mg

    The starting Qsymia dose is phentermine 3.75mg/topiramate 23mg, the pill is purple
    Titration

    11.25 mg/​69 mg

    The titration Qsymia dose is phentermine 11.25mg/topiramate 69mg, the pill is yellow
    Top

    15 mg/​92 mg

    The top Qsymia dose is phentermine 15mg/topiramate 92mg, the pill is yellow and white

    If you take too much Qsymia, call your healthcare provider or go to the nearest emergency room right away.

What to avoid when taking Qsymia

  • Do not get pregnant while taking Qsymia
  • Do not drink alcohol while taking Qsymia. Qsymia and alcohol can affect each other causing side effects such as sleepiness or dizziness
  • Do not drive a car or operate heavy machinery, or do other dangerous activities until you know how Qsymia affects you. Qsymia can slow your thinking and motor skills, and may affect vision

Qsymia can cause serious side effects, including:

  • Birth defects (cleft lip/cleft palate)
  • Increases in heart rate
  • Suicidal thoughts or actions
  • Serious eye problems

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* BMI (body mass index) measures the amount of fat in the body based on height and weight. BMI is measured in kg/m2.
Or a BMI of 27 or more with one weight-related medical condition.